Key result
Higher non-HDL cholesterol levels were significantly associated with poor coronary collateral circulation in patients with stable coronary artery disease (185.7 vs 132.8 mg/dl, p<0.001).
Why the study?
Non-HDL cholesterol correlates with CRP, a marker of inflammation related to poor coronary collateral circulation, but whether non-HDL-C itself is associated with CCC was unclear.
Are non-HDL-C levels associated with poor coronary collateral circulation in patients with stable coronary artery disease and an occluded epicardial artery?
Cross-Sectional (n=84)
No
Are non-HDL-C levels associated with poor coronary collateral circulation in patients with stable coronary artery disease and an occluded epicardial artery?
Higher non-HDL cholesterol levels are associated with poor angiographic coronary collateral circulation in patients with stable coronary artery disease and an occluded epicardial artery.
Non-HDL-C was associated with poor CCC in stable CAD; hypothesis-generating and requires prospective validation before any clinical use.
Objective Non high density lipoprotein cholesterol (non HDL-C) covers all aterojenic lipoproteins and correlates with C reactive protein (CRP) which is reliable marker of inflammation. CRP is related to poor angiographic coronary collateral circulation (CCC). We aimed to show whether non HDL-C is associated with CCC.Methods Patients who underwent coronary angiography for stable coronary artery disease and at least one epicardial coronary artery occluded in the proximal or middle region were included in the study. Accrording to the Rentrop scoring system Rentrop 0 and 1 were considered to be poor CCC, and Rentrop 2 and 3 were considered to be good CCC. Non-HDL-C was calculated by subtracting HDL-C from total cholesterol (TC).Results 84 patients were included in the study. While 44 patients (52%) had good CCC, 40 patients (48%) had poor CCC. TC was found to be higher in the poor CCC group than in the good CCC group (224.3 ± 35.6 vs 179.2 ± 25.5 p = 0.000). HDL-C levels were found to be lower in the poor CCC group than in the good CCC group (37.3 ± 9.8 vs 44.1 ± 8.6 p = 0.001). Non-HDL-C cholesterol levels were higher in the group with poor CCC (185.7 ± 39.2 vs 132.8 ± 28.1 p = 0.000). CRP levels were found to be higher in the poor CCC group (3.73 ± 2.5 vs 1.67 ± 1.4 p = 0,000).Conclusion Non-HDL-C is independent predictors of poor CCC.
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Yıldırım et al. (2020) conducted a cross-sectional in Stable coronary artery disease (n=84). Non-HDL cholesterol vs. Good coronary collateral circulation was evaluated on Poor coronary collateral circulation (OR 0.941, 95% CI 0.910-0.972, p=<0.001). Higher non-HDL cholesterol levels were significantly associated with poor coronary collateral circulation in patients with stable coronary artery disease (185.7 vs 132.8 mg/dl, p<0.001).
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