Key result
Implementation of patient-specific material data into numerical models increased peak wall stress by 67%, wall strain by 320%, and displacement by 177% compared with literature-based properties.
Why the study?
Does the use of patient-specific material properties alter the magnitudes of peak wall stress, strain, and displacement in computational simulations of abdominal aortic aneurysms compared to population-based data?
Case Report (n=1)
Does the use of patient-specific material properties alter the magnitudes of peak wall stress, strain, and displacement in computational simulations of abdominal aortic aneurysms compared to population-based data?
Effect estimate: increased peak wall stress by 67%, wall strain by 320% and displacement by 177%
Using patient-specific material properties in computational simulations of abdominal aortic aneurysms significantly alters the magnitude of stress and strain compared to population-based data, highlighting the need for caution when interpreting numerical results.
Patient-specific properties markedly alter AAA model outputs; hypothesis-generating and should not yet change clinical interpretation of simulations.
Patient-specific modelling of abdominal aortic aneurysm has been shown to have clinical potential. This paper examines a large ruptured abdominal aortic aneurysm where the tissue from the diseased wall and the intraluminal thrombus was excised during open surgical repair and experimentally characterised. The mechanical data were used to develop material parameters that were incorporated into finite element models with measured nonuniform wall thickness. Implementation of the material data into the numerical model increased peak wall stress by 67%, wall strain by 320% and displacement by 177%, when compared with simulations based on material properties available in the literature. Distributions of numerical results were similar for both material data. Magnitudes of numerical results can differ significantly when using patient-specific material properties and therefore, care should be taken when interpreting numerical results derived from population-based data.
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Doyle et al. (2012) conducted a case report in Abdominal aortic aneurysm (n=1). Patient-specific material properties in computational simulations vs. Simulations based on material properties available in the literature was evaluated on Peak wall stress, wall strain, and displacement (increased peak wall stress by 67%, wall strain by 320% and displacement by 177%). Implementation of patient-specific material data into numerical models increased peak wall stress by 67%, wall strain by 320%, and displacement by 177% compared with literature-based properties.
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