Key result
Type 2 diabetes mellitus was associated with significantly reduced vessel density in the deep and superficial capillary plexuses and choriocapillaris compared to healthy controls (p<0.001).
Why the study?
The study was conducted to analyze alterations in the density of retinal blood vessels and the choriocapillaris in patients with type 2 diabetes mellitus.
Does Type 2 Diabetes Mellitus reduce the density of retinal blood vessels and the choriocapillaris in patients without diabetic retinopathy?
Observational (n=116)
Does Type 2 Diabetes Mellitus reduce the density of retinal blood vessels and the choriocapillaris in patients without diabetic retinopathy?
p-value: p=<0.001
OCTA detects significant reductions in retinal and choriocapillaris vessel density in T2DM patients even before the clinical onset of diabetic retinopathy.
OCTA-detected vascular density reductions in T2DM without retinopathy may signal early microvascular changes; leaves open predictive utility for incident diabetic retinopathy.
Optical coherence tomography angiography (OCTA) was used to analyze the alterations in the density of retinal blood vessels and the choriocapillaris (VD) in patients suffering from type 2 diabetes mellitus (T2DM). One hundred sixty‐six eyes of 83 patients (43 of whom were men and 40 women, with a mean age of 58.59 ± 14.04) with T2DM and without diabetic retinopathy were examined for the purpose of conducting the observational prospective study. The control group (CG) consisted of 66 eyes in 33 healthy subjects (15 male and 18 female, with a mean age of 55.12 ± 12.70). The measurement regions of vessel density (VD) included the deep capillary plexus (DCP), the superficial capillary plexus (SCP), and the choriocapillaris. The results indicate considerable differences in the VD of the DCP and SCP when comparing the control group with the study groups ( p < 0.001). In comparison with the control group ( p < 0.001), there was a statistically significant reduction in the VD of the choriocapillaris in the study group. Furthermore, patients with T2DM showed a significantly decreased VD concerning the control in different macular regions. Thickness in several macular regions in the study group significantly decreased compared to the ones in the control group. OCTA was used to gather relevant information about the vascular changes which occurred in T2DM patients, assessed through the quantitative analysis of the blood flow in the retina and choriocapillaris.
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Zlatanović et al. (2021) conducted an observational in Type 2 diabetes mellitus (n=116). Type 2 diabetes mellitus vs. Healthy subjects was evaluated on Vessel density of the deep capillary plexus, superficial capillary plexus, and choriocapillaris (p=<0.001). Type 2 diabetes mellitus was associated with significantly reduced vessel density in the deep and superficial capillary plexuses and choriocapillaris compared to healthy controls (p<0.001).
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