Key result
A 12-week hypocaloric diet in obese women significantly decreased plasma apelin levels from 369+/-25 pg/ml to 257+/-12 pg/ml, along with reductions in BMI, insulin, and TNF-alpha.
Why the study?
Does a hypocaloric diet reduce plasma apelin and adipose tissue expression of apelin and APJ in obese women?
Does a hypocaloric diet reduce plasma apelin and adipose tissue expression of apelin and APJ in obese women?
A hypocaloric diet reduces elevated plasma apelin and adipose tissue expression of apelin in obese women, suggesting a mechanism for decreased circulating apelin levels with weight loss.
Authors
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Hypocaloric diet-associated apelin reduction in obese women is hypothesis-generating; leaves open mechanistic contribution to cardiometabolic benefits.
Castan‐Laurell et al. (2008) studied Obesity (n=32). Hypocaloric weight-reducing diet vs. Baseline (pre-diet) and healthy lean controls was evaluated on Fasting plasma levels of apelin and TNF-alpha, and mRNA levels of apelin and APJ in adipose tissue. A 12-week hypocaloric diet in obese women significantly decreased plasma apelin levels from 369+/-25 pg/ml to 257+/-12 pg/ml, along with reductions in BMI, insulin, and TNF-alpha.
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