Selective cytotoxic effect against the MDA-MB-468 breast cancer cell line of the antibacterial palindromic peptide derived from bovine lactoferricin

Andrea Carolina Barragán‐Cárdenas; Maribel Urrea-Pelayo; Victor Alfonso Niño‐Ramírez; Adriana Umaña‐Pérez; Jean‐Paul Vernot; Claudia Marcela Parra‐Giraldo; Ricardo Fierro‐Medina; Zuly Jenny Rivera‐Monroy; Javier Eduardo García‐Castañeda

doi:10.1039/d0ra02688c

January 1, 2020RSC AdvancesOpen Access

Selective cytotoxic effect against the MDA-MB-468 breast cancer cell line of the antibacterial palindromic peptide derived from bovine lactoferricin

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Key Points

Evaluate the cytotoxic potential of the bovine lactoferricin-derived palindromic peptide LfcinB (21–25)Pal and its alanine-substituted analogs against MDA-MB-468 breast cancer cells.
Synthesized the palindromic peptide LfcinB (21–25)Pal (sequence: RWQWRWQWR) derived from bovine lactoferricin.
Generated analogous peptide sequences using alanine scanning mutagenesis.
Assayed peptide-mediated cytotoxic effects in vitro using the human breast cancer cell line MDA-MB-468.
The antibacterial palindromic peptide LfcinB (21–25)Pal demonstrated cytotoxic activity against MDA-MB-468 breast cancer cells.
Alanine-substituted analogs displayed altered cytotoxic efficacy against the cancer cell line relative to the parental sequence.

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Implication

In vitro study demonstrates cytotoxic activity of bovine lactoferricin-derived peptides in MDA-MB-468 breast cancer cells, suggesting potential for novel peptide therapeutics.

Abstract

The cytotoxic effect against the breast cancer cell line MDA-MB-468 of the palindromic peptide LfcinB (21–25) Pal : 1 RWQWRWQWR 9 and its analogous peptides, obtained via alanine scanning, was evaluated.

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Barragán‐Cárdenas et al. (2020) studied this question.

synapsesocial.com/papers/6a9ab8b544c3282f559e3f3a https://doi.org/10.1039/d0ra02688c

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Selective cytotoxic effect against the MDA-MB-468 breast cancer cell line of the antibacterial palindromic peptide derived from bovine lactoferricin

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Selective cytotoxic effect against the MDA-MB-468 breast cancer cell line of the antibacterial palindromic peptide derived from bovine lactoferricin

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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