Key result
Challenge with homologous infectious bronchitis virus isolates provided 90-100% protection in chickens, whereas heterologous isolates provided an average of 38% protection.
Why the study?
Does prior infection with one isolate of avian infectious bronchitis virus provide cross-immunity against homologous and heterologous isolates in chickens?
Population
Groups of 75 chickens (plus susceptible controls)
Comparison
Infection with one of 7 isolates of infectious… vs Susceptible controls
Design
Preclinical
Follow-up
4 or 5 days post-challenge
Authors
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Strong homologous protection but weak heterologous cross-immunity in chickens; leaves open strain-specific vaccine strategies.
Does prior infection with one isolate of avian infectious bronchitis virus provide cross-immunity against homologous and heterologous isolates in chickens?
Prior infection with avian infectious bronchitis virus provides strong homologous protection but weak and variable heterologous cross-immunity in chickens.
M. S. Hofstad (1981) studied Avian Infectious Bronchitis Virus. Challenge with homologous and heterologous isolates of infectious bronchitis virus vs. Susceptible controls was evaluated on Cross-immunity (protection) determined by virus recovery. Challenge with homologous infectious bronchitis virus isolates provided 90-100% protection in chickens, whereas heterologous isolates provided an average of 38% protection.
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