Key result
Reduced flow-mediated dilation was a significant independent predictor of the presence of coronary artery disease (OR 1.78, P=0.032) and its severity (OR 1.85, P=0.005).
Why the study?
Does flow-mediated dilation (FMD) correlate with the presence and severity of coronary artery disease in patients undergoing coronary angiography?
Observational (n=89)
Does flow-mediated dilation (FMD) correlate with the presence and severity of coronary artery disease in patients undergoing coronary angiography?
Odds Ratio: 1.78
p-value: p=0.032
Brachial artery flow-mediated dilation is significantly reduced in patients with CAD and correlates with angiographic disease severity, suggesting its utility as a surrogate indicator of CAD burden.
May inform noninvasive CAD assessment on angiography; leaves open whether FMD adds value beyond standard predictors.
BACKGROUND: The use of flow-mediated dilation (FMD) as a surrogate indicator for the extent of coronary artery disease (CAD) remains largely unknown. We assessed FMD at the brachial artery in 89 consecutive patients undergoing coronary angiography. METHODS AND RESULTS: Patients were classified in groups 0 to 3 according to the number of diseased vessels and the SYNTAX score was calculated. The FMD decreased significantly from groups 0 to 3 (P < .001). There was a significant linear relation between SYNTAX score and FMD (corrected r (2) = .64, P < .001). In multivariate analysis, a reduced FMD was the only significant independent predictor of the presence of CAD (odds ratio [OR] 1.78, P = .032) and of CAD severity (OR 1.85, P = .005). CONCLUSION: This study confirms that FMD is reduced in patients with CAD and that such reduction in FMD is related to the extent of the disease. Therefore, FMD at the brachial artery is likely to represent a reliable indicator of CAD burden.
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Manganaro et al. (2014) conducted an observational in Coronary Artery Disease (n=89). Reduced flow-mediated dilation (FMD) was evaluated on Presence of CAD (OR 1.78, p=0.032). Reduced flow-mediated dilation was a significant independent predictor of the presence of coronary artery disease (OR 1.78, P=0.032) and its severity (OR 1.85, P=0.005).
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