Key result
Lower brachial artery FMD strongly correlates with a higher coronary stenosis index.
Why the study?
The relationship between flow-mediated dilation of the brachial artery and the extent and severity of coronary artery disease was examined to understand vascular impairment in CAD.
Does brachial artery flow-mediated dilation correlate with the angiographic severity of coronary artery disease?
Population
121 patients undergoing coronary arteriography
Comparison
Flow-mediated dilation across different severities of coronary artery disease
Design
Cross-sectional study
Authors
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FMD may serve as a non-invasive marker of CAD severity; leaves open its incremental prognostic value beyond standard assessments.
Cross-Sectional (n=121)
Does brachial artery flow-mediated dilation correlate with the angiographic severity of coronary artery disease?
Effect estimate: rs=-0.63
p-value: p=<0.0001
Brachial artery flow-mediated dilation is inversely correlated with the angiographic severity of coronary artery disease, suggesting its utility as a non-invasive marker of coronary atherosclerosis.
Kaku et al. (1998) conducted a cross-sectional in Coronary artery disease (n=121). Flow-mediated dilation (FMD) of the brachial artery vs. Patients without CAD was evaluated on Correlation between adjusted FMD and coronary stenosis index (CSI) (rs=-0.63, p=<0.0001). Adjusted brachial artery flow-mediated dilation correlated inversely with the coronary stenosis index (rs=-0.63, p<0.0001), indicating more severe impairment with worsening coronary atherosclerosis.
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