Key result
Topical ACE inhibitors decreased intraocular pressure and aqueous humor flow in rabbits as much as systemic CA inhibitors, but increased cerebrospinal fluid and pancreatic juice production.
Why the study?
Does ACE inhibition affect fluid production by the ciliary process, choroid plexus, and pancreas in rabbits?
Does ACE inhibition affect fluid production by the ciliary process, choroid plexus, and pancreas in rabbits?
ACE inhibitors decrease intraocular pressure and aqueous humor flow similarly to carbonic anhydrase inhibitors, but increase cerebrospinal fluid and pancreatic juice production in a rabbit model.
Animal data indicate organ-specific fluid effects; hypothesis-generating and should not inform clinical use.
Inhibitors of angiotensin converting enzyme (ACE) (1) and of carbonic anhydrase (CA) (2,3) decrease intraocular pressure (IOP) in conscious rabbits. We asked whether ACE inhibition decreases IOP through effects on CA-dependent flow of aqueous humor (AH) and whether ACE inhibitors decrease other CA-dependent secretions. We show in anesthetized rabbits (a) that topical inhibitors of ACE decrease both IOP and AH flow as much as systemic inhibitors of CA; (b) that the maximal effects of ACE and CA inhibition are not additive, therefore these treatments may affect one or more components of a single system for fluid production; and that (c) ACE inhibitors do not work through inhibition of CA. Looking at other fluid production systems, we find (d) that cerebrospinal fluid (CSF) production is increased after ventriculocisternal perfusion with a potent ACE inhibitor and (e) that flow of pancreatic juice (PJ) is increased after systemic ACE inhibition.
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Vogh et al. (1989) studied this question. ACE inhibitors vs. Carbonic anhydrase (CA) inhibitors was evaluated on Intraocular pressure (IOP), aqueous humor (AH) flow, cerebrospinal fluid (CSF) production, and pancreatic juice (PJ) flow. Topical ACE inhibitors decreased intraocular pressure and aqueous humor flow in rabbits as much as systemic CA inhibitors, but increased cerebrospinal fluid and pancreatic juice production.
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