Key result
A higher LDL-C to HDL-C ratio was an independent marker for the presence of endothelial dysfunction (OR 1.64; P=0.01) in patients undergoing coronary angiography.
Why the study?
The study investigated the associations between endothelial dysfunction evaluated by the reactive hyperemia index and atherosclerotic risk factors in patients undergoing coronary artery angiography.
Is the lipid profile associated with endothelial dysfunction in patients undergoing coronary angiography?
Observational (n=191)
Is the lipid profile associated with endothelial dysfunction in patients undergoing coronary angiography?
Odds Ratio: 1.64
p-value: p=0.01
The LDL-C/HDL-C ratio is an independent marker of endothelial dysfunction in patients without dyslipidemia, while HDL-C is an independent marker in statin-treated patients.
May aid endothelial risk stratification during angiography; hypothesis-generating and requires prospective validation before guiding therapy.
Introduction We investigated the associations between endothelial dysfunction (ED) as evaluated by the reactive hyperemia index (RHI) obtained using Endo-PAT2000® and atherosclerotic risk factors in patients who underwent coronary artery angiography (CAG).Methods The subjects consisted of 191 patients who were clinically suspected to have CAD and underwent CAG, and in whom we could perform Endo-PAT2000®. We divided the patients into ED (RHI<1.67, n = 71) and non-ED (RHI≥1.67, n = 120) groups.Results The ED group was significantly older and showed a higher ratio of low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) (L/H) than the non-ED group. A multivariate logistic regression analysis was performed to examine the associations between the presence of ED and age, gender, and BMI in addition to L/H. Age [odds ratio (OR) = 1.03, p = .02] and L/H (OR = 1.64, p = .01) were identified as significant independent markers of the presence of ED. Next, we divided 122 patients with statin treatment into ED (n = 40) and non-ED (n = 82) groups. The ED group tended to have higher L/H and lower HDL-C than the non-ED group. HDL-C (OR = 0.95, p = .01) and age (OR = 1.05, p = .04) were identified as independent markers of the presence of ED.Conclusions L/H was an independent marker of the presence of ED in patients without dyslipidemia. In addition, among patients with statin treatment, HDL-C was an independent marker of the presence of ED.
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Norimatsu et al. (2020) conducted an observational in Suspected coronary artery disease (n=191). LDL-C to HDL-C ratio (L/H) was evaluated on Presence of endothelial dysfunction (reactive hyperemia index < 1.67) (OR 1.64, p=0.01). A higher LDL-C to HDL-C ratio was an independent marker for the presence of endothelial dysfunction (OR 1.64; P=0.01) in patients undergoing coronary angiography.
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