Key result
Transcutaneous vagus nerve stimulation provides a safe, non-invasive method to modulate the autonomic nervous system and shows potential as a therapeutic tool for neuropsychiatric disorders.
Why the study?
The availability of safe, non-invasive transcutaneous vagus nerve stimulation techniques provides new opportunities to assess the role of the vagus nerve in psychiatric disorders.
The vagus nerve plays a crucial role in autonomic and inflammatory regulation, providing a theoretical and physiological basis for non-invasive transcutaneous vagus nerve stimulation as a potential therapeutic tool in neuropsychiatric disorders.
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Leaves open clinical adoption of tVNS in neuropsychiatric disorders; warrants prospective trials to test efficacy.
The vagus nerve (VN) plays an important role in the modulation of the autonomic nervous system, inflammatory system, and interoception, therefore connecting the cardiovascular and gastrointestinal systems to the central nervous system. Dysregulation of the VN is implicated in several psychiatric disorders. The recent availability of safe and non-invasive transcutaneous VN stimulation (tVNS) techniques opens new opportunities to evaluate the role of the VN in psychiatric disorders. We briefly review the basic anatomy and physiology of the VN, extensively discuss various theories linking VN dysfunction to health and illness, give details of the probable neurochemical underpinnings of VN activity, delineate its dysfunction in psychiatric disorders and put forward the current state and future directions of VNS, specifically focusing on tVNS.
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Nayok et al. (2023) conducted a review in Neuropsychiatric disorders. Vagus nerve stimulation was evaluated. Transcutaneous vagus nerve stimulation provides a safe, non-invasive method to modulate the autonomic nervous system and shows potential as a therapeutic tool for neuropsychiatric disorders.
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