Key result
Aortic stenosis induces high shear stress that cleaves von Willebrand factor multimers, causing an acquired deficiency and bleeding risk that resolves immediately following surgical valve replacement.
Why the study?
This systematic review aimed to gather further knowledge regarding the pathology of acquired Von Willebrand disease within patients with aortic stenosis.
Does aortic valve replacement resolve acquired von Willebrand deficiency in adults with aortic stenosis?
Population
Eight studies of patients with aortic stenosis
Design
Systematic review following PRISMA 2020 guidelines
Authors
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AVR resolves acquired VWD and bleeding risk in severe AS; confirms shear-stress mechanism and supports VWF-guided surgical timing.
Systematic Review (n=3,656)
Does aortic valve replacement resolve acquired von Willebrand deficiency in adults with aortic stenosis?
Acquired von Willebrand syndrome is a significant cause of bleeding in adults with aortic stenosis, and surgical valve replacement effectively restores VWF multimer levels and resolves the coagulopathy.
Ramesh et al. (2022) conducted a systematic review in Aortic Stenosis and Acquired Von Willebrand Deficiency (n=3,656). Aortic stenosis vs. Post-aortic valve replacement was evaluated on Acquired von Willebrand factor deficiency (loss of high molecular weight multimers). Aortic stenosis induces high shear stress that cleaves von Willebrand factor multimers, causing an acquired deficiency and bleeding risk that resolves immediately following surgical valve replacement.
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