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Two patients received large amounts of diphenylhydantoin for 28 months or more. While receiving diphenylhydantoin, they acquired severe cerebellar deficits and a peripheral neuropathy that was irreversible. In each case, marked cerebellar atrophy was demonstrated by pneumoencephalography. The cerebellar atrophy and irreversible dysfunction in these two cases is attributed to long-term, high dosages of diphenylhydantoin.
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Selhorst et al. (1972) studied this question.
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