Key result
The PON1 rs854560 polymorphism M allele was significantly associated with lower levels of high-density lipoprotein cholesterol (SMD -0.15) compared to non-carriers.
Why the study?
Previous studies investigating associations of the PON1 rs854560 polymorphism with plasma lipid levels yielded inconclusive results.
Does the PON1 rs854560 polymorphism affect plasma lipid levels in human subjects?
Meta-Analysis (n=22,844)
Does the PON1 rs854560 polymorphism affect plasma lipid levels in human subjects?
The PON1 rs854560 polymorphism (M allele) is associated with significantly lower levels of HDL-C and APOA1, particularly in Caucasians, which may contribute to an increased risk of coronary heart disease.
May heighten CHD risk via lower HDL-C in carriers; leaves open causal confirmation and any role for genetic testing in lipid management.
BACKGROUND: Previous studies have investigated the associations of paraoxonase 1 (PON1) rs854560 polymorphism with plasma lipid levels, but the results are inconclusive. This meta-analysis aimed to clarify the associations of the rs854560 polymorphism with plasma lipid levels. METHODS: A comprehensive search of the literature was carried out by using the databases which include Medline, Google Scholar, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang and VIP database up till August 2018. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was used to assess the differences in lipid levels between the genotypes. Begg's funnel plots and Egger's test were used to examine the publication bias. RESULTS: A total of 41 studies (22,844 subjects) were identified for the associations of rs854560 polymorphism with plasma lipid levels. The M carriers had lower levels of high-density lipoprotein Cholesterol (HDL-C) (SMD = - 0.15, 95% CI = - 0.23--0.07, P < 0.01) and apolipoprotein A-I (APOA1) (SMD = - 0.67, 95% CI = - 0.93--0.41, P < 0.01) than the non-carriers. Subgroup analysis by ethnicity revealed that the effect on HDL level was significant in Caucasians and the subjects of other ethnic origins. No publication bias was detected in this meta-analysis. CONCLUSIONS: The meta-analysis suggests that the PON1 rs854560 polymorphism is associated with a lower HDL-C level in Caucasians and subjects of other ethnic origins.
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Luo et al. (2018) conducted a meta-analysis in Dyslipidemia (n=22,844). PON1 rs854560 polymorphism (M allele carriers) vs. Non-carriers (LL genotype) was evaluated on High-density lipoprotein cholesterol (HDL-C) levels (SMD -0.15, 95% CI -0.23 to -0.07, p=< 0.01). The PON1 rs854560 polymorphism M allele was significantly associated with lower levels of high-density lipoprotein cholesterol (SMD -0.15) compared to non-carriers.
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