Key result
PON1 Leu-Met55 and Gln-Arg192 polymorphisms show no association with carotid IMT.
Why the study?
Are PON1 gene Leu-Met55 and Gln-Arg192 polymorphisms associated with carotid artery intima-media thickness in a general Caucasian population?
Cross-Sectional (n=999)
Are PON1 gene Leu-Met55 and Gln-Arg192 polymorphisms associated with carotid artery intima-media thickness in a general Caucasian population?
PON1 Leu-Met55 and Gln-Arg192 polymorphisms are not major risk factors for early atherosclerotic changes in the general Caucasian population.
No association does not support PON1 genotyping for atherosclerosis risk; leaves open relevance in progression or non-Caucasian groups.
BACKGROUND: Paraoxonase-1 (PON1) is an enzyme that prevents low-density lipoprotein (LDL) oxidation. The role of polymorphisms of PON1 determining early atherosclerotic changes is currently unclear. DESIGN: Cross sectional cohort study. METHODS: Nine hundred and ninety-nine subjects from a population-based cohort were screened. Intima-media thickness (IMT) was measured by ultrasonography. Leu-Met55 and Gln-Arg192 polymorphism were determined. RESULTS: No association between PON1 genotypes and IMT was found. This finding remained after adjusting for confounding factors. CONCLUSIONS: The PON1 Leu-Met55 and Gln-Arg192 polymorphisms are not major risk factors for atherosclerosis in the general Caucasian population.
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Karvonen et al. (2004) conducted a cross-sectional in carotid artery atherosclerosis (n=999). PON1 Leu-Met55 and Gln-Arg192 polymorphisms was evaluated on Intima-media thickness (IMT). PON1 Leu-Met55 and Gln-Arg192 polymorphisms were not associated with carotid intima-media thickness in a population-based cohort.
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