Key result
PON2 311C allele is linked to ~120% higher risk of severe ischemic stroke.
Why the study?
Paraoxonase gene polymorphisms may affect enzyme activity involved in atherosclerosis, but their association with ischemic stroke severity is unclear.
Are PON gene polymorphisms associated with ischemic stroke susceptibility and severity?
Case-Control (n=359)
Are PON gene polymorphisms associated with ischemic stroke susceptibility and severity?
Odds Ratio: 2.215
p-value: p=0.02
The PON2 311C allele may serve as a predisposing genetic factor for severe cases of ischemic stroke, despite not being associated with overall stroke susceptibility.
Does not support genetic testing in stroke care; leaves open PON2 role in severity prediction.
BACKGROUND: Paraoxonase (PON) is an HDL-associated enzyme that prevents low-density lipoprotein oxidation, playing a major role in the pathogenesis of atherosclerosis. PON genes polymorphisms may affect the corresponding enzyme activity. In this study, we examined the association of ischemic stroke with the three PON genes. METHODS: One hundred and seventy-eight patients hospitalized for ischemic stroke and 181 age- and sex-matched healthy controls were recruited. PON1(Q/R) 192, PON1(M/L) 55, and PON2(S/C) 311 polymorphisms were analyzed. RESULTS: The presence of the PON2 311C allele was significantly increased in patients with severe forms of ischemic stroke according to Modified Rankin Scale (P = 0.02, odds ratio = 2.215). No significant differences in genotype and allele distribution were observed between patients and controls. CONCLUSIONS: The PON2 311C allele was suggested as a possible predisposing factor for severe cases of ischemic stroke. Large-scale multicenter-controlled prospective studies are warranted to further explore the effects of PON polymorphisms on stroke susceptibility and severity.
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Lazaros et al. (2009) conducted a case-control in Ischemic stroke (n=359). Paraoxonase (PON) gene polymorphisms vs. Healthy controls was evaluated on Severe forms of ischemic stroke according to Modified Rankin Scale (OR 2.215, p=0.02). The presence of the PON2 311C allele was significantly associated with severe forms of ischemic stroke according to the Modified Rankin Scale (OR 2.215, P=0.02).
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