Key result
PON1 Q192R and L55M polymorphisms and paraoxonase activity show no association with atherothrombotic stroke.
Why the study?
The PON1 genotype has been associated with cardiovascular diseases including stroke, but its role as a risk factor for atherothrombotic stroke in Mexican patients was unclear.
Are PON1 L55M and Q192R polymorphisms and enzymatic activities risk factors for atherothrombotic stroke?
Case-Control (n=57)
Are PON1 L55M and Q192R polymorphisms and enzymatic activities risk factors for atherothrombotic stroke?
PON1 Q192R and L55M polymorphisms and paraoxonase activity do not appear to be independent risk factors for atherothrombotic stroke in this Mexican cohort.
No association in this case-control study should not change clinical risk assessment; leaves open PON1's role in stroke pending larger studies.
BACKGROUND: The serum paraoxonase-1 (PON1) associated to HDL presents two common polymorphisms in the positions 192 and 55. These polymorphisms are considered determinant of the capacity of HDL to protect LDL from their oxidative modification. In this context, the PON1 genotype has been associated with cardiovascular diseases, including stroke. OBJECTIVE: To determine the allelic and genotypic frequencies of PON1 L55M and Q192R as well as the enzymatic activities of PON1 in subjects with and without atherothrombotic stroke. METHODS: There were included 28 people with atherothrombotic stroke and 29 without stroke. The genotyping was carried out by PCR-RFLP and the phenotyping by measurement of the activities of paraoxonase and arylesterase in serum. RESULTS: = 0.001); however, upon adjustment by multiple linear regression, it was not longer significant. CONCLUSION: The polymorphisms Q192R and L55M, and the paraoxonase activity of PON1 are not risk factors for atherothrombotic stroke according to the results of this study.
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Martínez-Salazar et al. (2018) conducted a case-control in Atherothrombotic stroke (n=57). PON1 L55M and Q192R polymorphisms vs. Other genotypes was evaluated on Atherothrombotic stroke. PON1 Q192R and L55M polymorphisms and paraoxonase activity were not significantly associated with atherothrombotic stroke after adjustment by multiple linear regression.
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