ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

Zhaomin Li; Peng Zhang; Aimin Yan; Zhengyu Guo; Yuguang Ban; Jin Li; Chen Shi; Hui Yang; Yongzheng He; Jianping Li; Ying Guo; Wen Zhang; Ehsan Hajiramezanali; Huangda An; Darlene Fajardo; J. William Harbour; Yijun Ruan; Stephen D. Nimer; Peng Yu; Xi Chen; Mingjiang Xu; Feng‐Chun Yang

doi:10.1126/sciadv.1601602

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Abstract

reduces the genome binding of RAD21 and SMC1A and alters the expression of ASXL1/cohesin target genes in LK cells. Our study underscores the ASXL1-cohesin interaction as a novel means to maintain normal sister chromatid separation and regulate gene expression in hematopoietic cells.

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Li et al. (2017) studied this question.

synapsesocial.com/papers/6a9ac713262e4da96990c175 https://doi.org/10.1126/sciadv.1601602

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ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

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Abstract

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ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

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