Key result
Increases in LDL-cholesterol (β = 0.173, p < 0.05) and annual change in triglyceride (β = 0.175, p < 0.05) were independently associated with the rate of progression of carotid maximum IMT in CKD.
Why the study?
Factors associated with the change in carotid maximum intima-media thickness in patients with moderate-to-advanced stage CKD were not fully determined.
Observational (n=130)
No
Effect estimate: β 0.173 (LDL-cholesterol) and β 0.175 (triglyceride change)
p-value: p=<0.05
In patients with moderate-to-advanced chronic kidney disease, higher LDL-cholesterol and increases in triglycerides are independently associated with faster progression of carotid atherosclerosis as measured by intima-media thickness.
May warrant lipid monitoring in CKD; leaves open whether targeting LDL or triglycerides slows carotid atherosclerosis.
PURPOSE: The objective of this study was to determine factors associated with the change in carotid maximum intima-media thickness (IMT), an established surrogate marker of atherosclerosis, in moderate-to-advanced stage chronic kidney disease (CKD) patients. METHODS: In total, 130 moderate-to-advanced stage CKD patients (mean age: 67.6 ± 11.0 years old; 91 men and 39 women) were included in this retrospective, single-center, observational study. Relationships between the change in carotid maximum IMT and clinical and laboratory data were analyzed by using multivariate linear regression analyses. RESULTS: Mean observation period was 2.9 ± 1.6 years. Mean carotid maximum IMT at baseline was 2.2 ± 1.0 mm, and the annual change in carotid maximum IMT was 0.06 ± 0.22 mm/year. Low-density lipoprotein (LDL)-cholesterol (β = 0.173, p < 0.05) and annual change in triglyceride (β = 0.175, p < 0.05) independently correlated with the annual change in carotid maximum IMT. CONCLUSION: Increases in LDL-cholesterol and triglyceride were associated with the rate of progression of carotid maximum IMT in moderate-to-advanced stage CKD patients.
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Hirai et al. (2020) conducted an observational in moderate-to-advanced stage chronic kidney disease (n=130). LDL-cholesterol and triglyceride levels was evaluated on annual change in carotid maximum IMT (β 0.173 (LDL-cholesterol) and β 0.175 (triglyceride change), p=<0.05). Increases in LDL-cholesterol (β = 0.173, p < 0.05) and annual change in triglyceride (β = 0.175, p < 0.05) were independently associated with the rate of progression of carotid maximum IMT in CKD.
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