Key result
Acute normobaric hypoxia significantly decreased the amplitudes of the maximum extrema of cardiac electric potentials, including a decrease in maximum amplitude from 1.88 mV to 1.83 mV.
Why the study?
Acute hypoxia deteriorates cardiac function and increases ventricular depolarization heterogeneity, which is difficult to detect using traditional ECG.
Does acute normobaric hypoxia alter the electrical activity of the heart during ventricular depolarization in healthy young men?
Observational
Does acute normobaric hypoxia alter the electrical activity of the heart during ventricular depolarization in healthy young men?
Acute normobaric hypoxia in healthy young men reduces the amplitude of cardiac electric potentials during ventricular depolarization without altering its duration or spatio-temporal distribution.
Answers are grounded in this paper and cite their sources.
Acute hypoxia may subtly reduce ECG amplitudes in healthy men; leaves open clinical relevance and need for patient studies.
Background. The effect of acute hypoxia on the human heart leads to deterioration of the heart function, this is reflected in an increase of the heterogeneity of the depolarization process, which is difficult to reveal when using a traditional ECG. Purpose. To investigate the electrical activity of the heart during the ventricular depolarization on the thorax surface under the exposure of acute normobaric hypoxia using multichannel ECG mapping. Material and methods. The electrical activity of the heart in apparently healthy young men (20±1 years) was studied during ventricular depolarization under exposure of acute normobaric hypoxia using cardioelectrotopography. Unipolar ECGs were recorded from 64 electrodes on the surface of the chest, simultaneously with bipolar ECGs in limb leads and the amplitudes of R and S waves from the surface electrodes localized in positions V1 and V5 of the traditional ECG were evaluated. Results. It was revealed that during hypoxia, in comparison with the initial state, the pattern of distribution and the spatio-temporal dynamics of positive and negative cardiac potentials reflecting the sequence of myocardial activation on the torso surface did not change significantly and were typical for the period of ventricular depolarization of the healthy person. A decrease in the amplitudes of the maximum extrema of cardiac electric potentials, the amplitudes of the SV1 and RV5 waves at hypoxic exposure was revealed: the amplitude of the maximum decreased from 1.88±0.58 mV in the initial state to 1.83±0.55 mV at hypoxia, the minimum – from -2.08±0.76 mV to -1.85±0.73 mV, the SV1 wave from -1.28±0.25 mV to -1.17±0.18 mV, RV5 wave from 1.21±0.25 mV to 1.05±0.29 mV, respectively, while the duration of ventricular depolarization did not change statistically significantly. Conclusion. Under hypoxic exposure, the examined persons showed a significant decrease in the amplitudes of the maximum extrema of the electric field of the heart, a direct correlation between changes in the amplitudes of the positive extremum and the RV5 wave, with practically unchanged duration of ventricular depolarization and dynamics of the distribution of cardioelectric potentials.
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Zamenina et al. (2023) conducted an observational in Healthy. Acute normobaric hypoxia vs. Initial state (baseline) was evaluated on Amplitude of the maximum extrema of cardiac electric potentials. Acute normobaric hypoxia significantly decreased the amplitudes of the maximum extrema of cardiac electric potentials, including a decrease in maximum amplitude from 1.88 mV to 1.83 mV.
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