Key result
Acute normobaric hypoxia is linked to ventricular repolarization changes that vary by baseline hypoxia resistance.
Why the study?
Does exposure to normobaric hypoxic hypoxia alter ventricular repolarization differently based on baseline resistance to hypoxia in healthy subjects?
Observational
Does exposure to normobaric hypoxic hypoxia alter ventricular repolarization differently based on baseline resistance to hypoxia in healthy subjects?
Acute hypoxia alters ventricular repolarization differently depending on an individual's baseline resistance to hypoxia, affecting specific phases of the QT interval.
Acute hypoxia alters repolarization variably by resistance; hypothesis-generating for arrhythmia risk and requires prospective validation before clinical consideration.
The study of the electrical activity of the heart during ventricular repolarization period of healthy subjects with different resistances to oxygen deficiency to exposure of normobaric hypoxic hypoxia (12.3% O2) has been carried out using the simultaneous recording of the heart electrical unipolar potentials from a variety of leads on the body surface. It was revealed that in subjects with different resistances to a hypoxic stimulus the correlation of change in QT, J-TpeakII and Tpeak-TendII intervals under the influence of acute hypoxia was different: in subjects with a high resistance to hypoxia the decrease in the QT interval corresponded to the decrease in ventricular late repolarization duration, and in subjects with low resistance to hypoxia the decrease in the QT interval corresponded to the periods of early and late repolarization. The analysis of the cardioelectric field on the body surface of subjects with different resistances to a hypoxic stimulus revealed a statistically significant decrease in temporal characteristics of maximum cardioelectric potentials while amplitude characteristics remained practically unchanged independently of resistance to hypoxia.
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Zamenina et al. (2019) conducted an observational in Healthy subjects with different resistances to oxygen deficiency. Normobaric hypoxic hypoxia (12.3% O2) vs. Different resistance groups was evaluated on Electrical activity of the heart during ventricular repolarization (QT, J-TpeakII and Tpeak-TendII intervals). Acute normobaric hypoxia (12.3% O2) caused different repolarization changes depending on hypoxia resistance, with a significant decrease in temporal characteristics of maximum potentials.
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