Key result
PAD-4 autocitrullination inactivates the enzyme, modifies its structure, and regulates the production of citrullinated proteins during cell activation, with efficiency differing among RA variants.
Autocitrullination of PAD-4 inactivates the enzyme and alters its structure, regulating protein citrullination and influencing immune responses relevant to rheumatoid arthritis.
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Animal data on PAD-4 autocitrullination are hypothesis-generating for RA variant mechanisms; human studies required before any clinical consideration.
Andrade et al. (2010) studied Rheumatoid arthritis. PAD-4 autocitrullination was evaluated on PAD-4 autocitrullination and functional consequences. PAD-4 autocitrullination inactivates the enzyme, modifies its structure, and regulates the production of citrullinated proteins during cell activation, with efficiency differing among RA variants.
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