Key result
Interleukins, including IL-1 through IL-10, are integral to the pathogenesis of coronary heart disease through their roles in promoting inflammation, endothelial dysfunction, plaque formation, and thrombosis.
Why the study?
Interleukins play a critical role in the pathogenesis of coronary heart disease by mediating inflammation, warranting a summary of their specific roles.
Interleukins play a critical role in the inflammatory pathogenesis of coronary heart disease and represent potential biomarkers and therapeutic targets.
Supports interleukin-targeted research in coronary heart disease; leaves open clinical translation pending prospective trials.
Interleukins (ILs), a subset of cytokines, play a critical role in the pathogenesis of coronary heart disease (CHD) by mediating inflammation. This review article summarizes the role of ILs such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, and IL-10 in the pathogenesis of CHD. Individuals with mild coronary artery disease (CAD) and angina who have ischemic heart disease have higher serum concentrations of IL-1b. Larger studies are needed to verify the safety and assess the effectiveness of low-dose IL-2 as an anti-inflammatory treatment. IL-3 is found more often in patients receiving coronary angioplasty compared to patients with asymptomatic CAD or without CAD. Serum levels of IL-4 are reliable indicators of CAD. An independent correlation between IL-5 and the incidence of CAD was demonstrated. IL-6 helps serve as a reliable biomarker for the degree of CAD, as determined by the Gensini score, and is a key factor in the development of atherosclerosis. Also, variants of IL-7/7R have been linked to the Han Chinese population's genetic susceptibility to CHD. IL-8 plays a role in the progression of CAD occurrences. By interacting with conventional risk factors for CAD, IL-9 may contribute to the development of CAD and offer an innovative approach to its prevention and management. There was a 34% increased risk of a CHD incident for every standard deviation rise in baseline IL-10 levels.
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Rafaqat et al. (2025) conducted a review in Coronary heart disease. Interleukins was evaluated. Interleukins, including IL-1 through IL-10, are integral to the pathogenesis of coronary heart disease through their roles in promoting inflammation, endothelial dysfunction, plaque formation, and thrombosis.
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