Key result
Barium, cadmium, calcium, lead, and strontium activated recombinant human SK4 channels in a concentration-dependent manner, with calcium being the most potent.
Calcium, lead, cadmium, strontium, and barium activate recombinant human SK4 channels in a concentration-dependent manner, providing insight into the ion selectivity and activation mechanisms of these channels.
No direct clinical implications from recombinant data; leaves open in vivo effects of these cations on native SK4 channels.
The effects of metal cations on the activation of recombinant human SK4 (also known as hIK1 or hKCa4) channels, expressed in HEK 293 cells, were tested using patch clamp recording. Of the nine metals tested, cobalt, iron, magnesium, and zinc did not activate the SK4 channels when applied, at concentrations up to 100 microM, to the inside of SK4 channel-expressing membrane patches. Barium, cadmium, calcium, lead, and strontium activated SK4 channels in a concentration-dependent manner. The rank order of potency was at Ca2+ > Pb2+ > Cd2+ > Sr2+ > Ba2+.
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Cao et al. (1999) studied this question. Metal cations was evaluated on Activation of SK4 channels. Barium, cadmium, calcium, lead, and strontium activated recombinant human SK4 channels in a concentration-dependent manner, with calcium being the most potent.
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