Key result
C-type natriuretic peptide mediates relaxation of canine femoral veins through activation of large-conduction, calcium-activated potassium channels and particulate and soluble guanylate cyclase.
CNP mediates relaxation of canine femoral veins through activation of large-conduction, calcium-activated potassium channels and activation of particulate and soluble guanylate cyclase.
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Hypothesis-generating in canine models; leaves open translation to human venous physiology.
Banks et al. (1996) studied this question. C-type natriuretic peptide (CNP) was evaluated on Mechanism of relaxation (isometric force in organ chambers). C-type natriuretic peptide mediates relaxation of canine femoral veins through activation of large-conduction, calcium-activated potassium channels and particulate and soluble guanylate cyclase.
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