July 1, 1998Journal of Cardiovascular Pharmacology
Gender and Relaxation to C-Type Natriuretic Peptide in Porcine Coronary Arteries
Key result
CNP induces less coronary relaxation in male versus female pigs, driven by channel, receptor, and PDE differences.
Why the study?
Does relaxation to C-type natriuretic peptide in porcine coronary arteries vary by gender?
Population
Rings of coronary arteries without endothelium from sexually mature male and female Yorkshire pigs
Comparison
C-type natriuretic peptide (CNP) (10(-9)-10(-7) M) vs Male vs. female porcine coronary arteries
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for sex-specific CNP coronary effects; leaves open translation to human physiology or therapy.
Structured PICO
Does relaxation to C-type natriuretic peptide in porcine coronary arteries vary by gender?
P
Population
Rings of coronary arteries without endothelium from sexually mature male and female Yorkshire pigs.
I
Intervention
C-type natriuretic peptide (CNP) (10(-9)-10(-7) M)
C
Comparator
Male vs. female porcine coronary arteries
O
Outcome
Relaxation of coronary arterial smooth muscle (measured by isometric force)surrogate
This preclinical study demonstrates that gender differences in CNP-mediated relaxation of coronary arteries are influenced by Ca2+-activated K+ channels, clearance receptors, and phosphodiesterase activity.
Cite This Study
Barber et al. (1998) studied this question. C-type natriuretic peptide (CNP) vs. Male vs female arteries was evaluated on Relaxations of coronary arterial smooth muscle to CNP. Relaxations to C-type natriuretic peptide were significantly less in coronary arteries from male compared with female pigs, driven by differences in K+ channels, clearance receptors, and PDE activity.