Key result
Mexiletine was more effective than quinidine in controlling ventricular couplets and ventricular tachycardia during acute testing (69.2% vs 41.0%; P<0.001) and resulted in fewer proarrhythmic events.
Why the study?
Does mexiletine improve the control of ventricular couplets and ventricular tachycardia compared to quinidine in patients with these arrhythmias?
Population
114 consecutive patients with ventricular couplets (VC) and ventricular tachycardia (VT)
Comparison
Mexiletine vs Quinidine
Design
Cohort
Follow-up
Mean 27 +/- 14 months for mexiletine and 21 +/- 14 months…
Authors
Loading...
Mexiletine may offer better acute ventricular arrhythmia control with fewer proarrhythmic events than quinidine; leaves open confirmation in randomized trials.
Cohort (n=114)
Does mexiletine improve the control of ventricular couplets and ventricular tachycardia compared to quinidine in patients with these arrhythmias?
Absolute Event Rate: 69.2% vs 41%
p-value: p=<.001
Mexiletine is more effective and less proarrhythmic than quinidine for controlling ventricular couplets and ventricular tachycardia, supporting its use as an initial antiarrhythmic choice.
Frank et al. (1991) conducted a cohort in Ventricular couplets and ventricular tachycardia (n=114). Mexiletine vs. Quinidine was evaluated on Control of ventricular couplets and ventricular tachycardia during acute drug testing (p=<.001). Mexiletine was more effective than quinidine in controlling ventricular couplets and ventricular tachycardia during acute testing (69.2% vs 41.0%; P<0.001) and resulted in fewer proarrhythmic events.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: