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A patient with a malignant thymoma developed systemic lupus erythematosus with neurological involvement and multiple infectious complications, including progressive multifocal leukoencephalopathy and cryptococcal meningitis. Data from this patient and studies by others are consistent with the concept that all cases of progressive multifocal leukoencephalopathy are associated with a defect in cellular immunity.
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Malas et al. (1977) studied this question.
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