Q Fever Down the Drain

MECAMYLAMINE IN HYPERTENSIONMBRrnSH 425from the alimentary canal, so that the oral dose is little more than the parenteral dose.The degree of drug toleration is slight, and is not sufficient to cause difficulty in determining the requisite dose of the drug.The action is more prolonged than that of pentolinium or of chlorisondamine, so that the degree of control over the blood-pressure level is better, provided that a sufficient dose can be administered.Adequate control over the blood-pressure level is hindered in some instances by the occurrence of parasympathetic side-effects, which appear to be rather more prominent in most cases than those we have encountered with pentolinium.There are, how- ever, individual differences in patients such that, with equal falls of blood pressure, side-effects may be less in some patients when they are treated with mecamylamine and less in others when they are treated with pentolinium.Mecamylamine may be used satisfactorily in combina- tion with rauwolfia alkaloids.Delayed toxicity has not been encountered with mecamylamine during our ex- perience of eight months.