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August 11, 2012European Journal of Cardio-Thoracic SurgeryOpen Access

Transapical aortic valve replacement in extreme-risk patients: outcome, risk factors and mid-term results

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Key result

Transapical transcatheter aortic valve replacement in extreme-risk patients resulted in a 20% hospital mortality rate and a 54% overall survival rate at 2 years.

Why the study?

Does transapical TAVR provide acceptable survival and clinical outcomes in extreme-risk patients with logistic EuroSCORE > 35%?

Population

40 'extreme-risk' patients with logistic EuroSCORE above 35%, mean age 81 ± 10 years.

Design

Cohort

Follow-up

mean 24 months

Authors

EFEnrico FerrariJNJ. NamasivayamCMCarlo Marcucci

Discussion

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Overview

High periprocedural mortality warrants caution for transapical TAVR in extreme-risk patients; leaves open net benefit versus medical management.

Study Design

Type

Cohort (n=40)

Structured PICO

Does transapical TAVR provide acceptable survival and clinical outcomes in extreme-risk patients with logistic EuroSCORE > 35%?

P
Population
40 extreme-risk patients (mean age 81 years, mean logistic EuroSCORE 48%) undergoing transapical transcatheter aortic valve replacement, followed for a mean of 24 months.
E
Exposure
Transapical transcatheter aortic valve replacement (TA-TAVR)
O
Outcome
Hospital and mid-term mortality (up to 2-year follow-up)hard clinical

Transapical TAVR in extreme-risk patients (EuroSCORE >35%) carries a 20% hospital mortality risk, but survivors demonstrate acceptable mid-term survival and good clinical condition without heart failure rehospitalizations.

Cite This Study

Ferrari et al. (2012) conducted a cohort in Extreme-risk aortic valve disease (n=40). Transapical transcatheter aortic valve replacement (TA-TAVR) was evaluated on Hospital mortality. Transapical transcatheter aortic valve replacement in extreme-risk patients resulted in a 20% hospital mortality rate and a 54% overall survival rate at 2 years.

synapsesocial.com/papers/6a9afdd2d7741531f663bad7https://doi.org/10.1093/ejcts/ezs458
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