Key result
SGK1.1 upregulates the Kv7.2/3 M-current by increasing channel membrane abundance, leading to reduced neuronal excitability and diminished sensitivity to kainic acid-induced seizures in mice.
Population
Xenopus laevis oocytes, human embryonic kidney cells, and transgenic mice expressing a constitutively active…
Comparison
Expression of SGK1.1 or its constitutively… vs Control.
Design
Preclinical
Authors
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May identify SGK1.1 as an antiseizure target in mice; leaves open translation to human epilepsy.
SGK1.1 acts as a physiological regulator of the M-current, reducing neuronal excitability and protecting against seizures.
Miranda et al. (2013) studied Seizures and Neuronal Excitability. SGK1.1 (Neuronal Serum- and Glucocorticoid-Regulated Kinase 1.1) vs. Wild-type or control cells/mice was evaluated on M-current levels and neuronal excitability. SGK1.1 upregulates the Kv7.2/3 M-current by increasing channel membrane abundance, leading to reduced neuronal excitability and diminished sensitivity to kainic acid-induced seizures in mice.
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