Key result
Angiotensin II increases neuronal excitability and suppresses Kv7.2/7.3 currents via depletion of membrane phosphatidylinositol 4,5-bisphosphate (PIP2).
Population
Superior cervical ganglion sympathetic neurons and Chinese hamster ovary cells expressing cloned Kv7.2 + 7.3…
Comparison
Angiotensin II (angioII) application vs Baseline/control conditions
Design
Preclinical
Authors
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Does not support clinical translation; leaves open whether PIP2 modulation targets sympathetic hyperactivity in human cardiovascular disease.
Angiotensin II increases neuronal excitability by suppressing M-type K+ currents via depletion of membrane phosphatidylinositol 4,5-bisphosphate (PIP2).
Zaika et al. (2006) studied this question. Angiotensin II vs. Baseline/control was evaluated on Neuronal excitability and Kv7.2/7.3 current suppression. Angiotensin II increases neuronal excitability and suppresses Kv7.2/7.3 currents via depletion of membrane phosphatidylinositol 4,5-bisphosphate (PIP2).
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