Nephrocalcinosis in Adolescent Sprague-Dawley Rats Fed Casein and Different Salt Mixtures

Young Sprague-Dawley rats fed on semi-purified casein-containing diets developed nephrocalcinosis. The incidence of renal calculi was higher in females than in males and higher for diets containing 10% protein than those containing 20% protein. The nephrocalcinosis was more severe when a salt mixture containing rather high amounts of iodine and possibly deficient in magnesium and zinc was employed.