Key result
Single or double vaccination with the CSFV E2 subunit vaccine significantly reduced transplacental transmission of moderate-virulent CSFV to fetuses compared to unvaccinated controls (p <0.001).
Why the study?
Does single or double vaccination with CSFV E2 subunit vaccine prevent transplacental transmission of moderate-virulent CSFV in pregnant sows?
Population
27 sows, challenged intranasally with 10 TCID50 of a moderate-virulent strain of CSFV at approximately six…
Comparison
CSFV E2 subunit vaccine, administered either… vs Unvaccinated control group of 9 inseminated sows.
Design
Preclinical
Follow-up
5 weeks after challenge
Authors
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May limit CSFV spread in breeding sows; leaves open field validation before practice adoption.
Does single or double vaccination with CSFV E2 subunit vaccine prevent transplacental transmission of moderate-virulent CSFV in pregnant sows?
Absolute Event Rate: 0% vs 100%
p-value: p=<0.001
Vaccination with the CSFV E2 subunit vaccine significantly reduces the transplacental transmission of moderate-virulent CSFV from sows to their offspring.
Smit et al. (2000) studied Classical swine fever virus (CSFV) infection (n=27). CSFV E2 subunit vaccine vs. Unvaccinated controls was evaluated on Transplacental transmission of CSFV (detection in fetuses) (p=<0.001). Single or double vaccination with the CSFV E2 subunit vaccine significantly reduced transplacental transmission of moderate-virulent CSFV to fetuses compared to unvaccinated controls (p <0.001).
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