Key result
Cultured glioma cells demonstrated a 2.1-fold higher rate of ouabain-sensitive K+ uptake and a 2.4-fold higher [Na++ K+]ATPase activity compared to neuroblastoma cells.
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Higher Na/K-ATPase activity in glioma cells may guide targeted research; leaves open clinical relevance from Level 5 cell data.
Abstract —The ouabain‐sensitive K+ uptake and ATPase activities of cultured glioma and neuroblastoma cells were studied. Both cell lines showed ouabain‐sensitive K+ uptake which correlated with the level of [Na++ K+]ATPase activity found in the respective total cell homogenate. The glioma cells had a 2.1‐fold higher rate of K+ uptake than neuroblastoma cells, and a 2.4‐fold higher [Na++ K+]ATPase activity. In the presence of ouabain neuroblastoma cells released K+ and took up Na+ in a 1:1 ratio. These results are compared and contrasted with similar studies on brain tissue and isolated cells. It is suggested that the cultured cell lines may serve as good models for the cation transport properties of their tissue counterparts.
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Harold K. Kimelberg (1974) studied Cultured glioma and neuroblastoma cells. Ouabain vs. Neuroblastoma cells vs Glioma cells was evaluated on Ouabain-sensitive K+ uptake and [Na++ K+]ATPase activity. Cultured glioma cells demonstrated a 2.1-fold higher rate of ouabain-sensitive K+ uptake and a 2.4-fold higher [Na++ K+]ATPase activity compared to neuroblastoma cells.
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