Key result
Human chorionic gonadotropin (hCG) markedly stimulated macrophage migration inhibitory factor (MIF) expression in endometrial stromal cells predominantly by up-regulating MIF gene transcription.
Why the study?
Does human chorionic gonadotropin stimulate macrophage migration inhibitory factor expression in human endometrial stromal cells?
Population
Human endometrial stromal cells
Comparison
Human chorionic gonadotropin (hCG) treatment vs Untreated cells
Design
Preclinical
Authors
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hCG transcriptionally upregulates endometrial MIF in vitro; leaves open any role in human implantation or pregnancy outcomes.
Does human chorionic gonadotropin stimulate macrophage migration inhibitory factor expression in human endometrial stromal cells?
hCG markedly stimulates MIF expression in human endometrial stromal cells via up-regulation of gene transcription, revealing a potential mechanism for sustaining pregnancy and promoting embryonic growth.
Akoum et al. (2005) studied this question. Human chorionic gonadotropin (hCG) was evaluated on MIF protein secretion and mRNA steady-state levels. Human chorionic gonadotropin (hCG) markedly stimulated macrophage migration inhibitory factor (MIF) expression in endometrial stromal cells predominantly by up-regulating MIF gene transcription.
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