February 1, 1999Human Reproduction
Induction of macrophage migration inhibitory factor in human ovary by human chorionic gonadotrophin
Key result
HCG stimulation linked to an ~8-fold increase in serum MIF over baseline.
Why the study?
Does human chorionic gonadotrophin (HCG) stimulation increase macrophage migration inhibitory factor (MIF) concentrations in patients undergoing IVF?
Population
Patients undergoing in-vitro fertilization (IVF) and embryo transfer, and granulosa cells obtained from them
Comparison
Human chorionic gonadotrophin… vs Baseline, natural cycles, or withheld…
Design
Other
Authors
Discussion
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Implication
HCG-induced MIF rise in IVF cycles is hypothesis-generating for ovulatory mechanisms; leaves open any role in clinical outcomes or practice change.
Study Design
Type
Observational
Structured PICO
Does human chorionic gonadotrophin (HCG) stimulation increase macrophage migration inhibitory factor (MIF) concentrations in patients undergoing IVF?
P
Population
Patients undergoing in-vitro fertilization (IVF) and embryo transfer, evaluated for macrophage migration inhibitory factor levels during ovarian stimulation.
E
Exposure
Human chorionic gonadotrophin (HCG) administration/stimulation
C
Comparator
Baseline (before HCG administration), natural cycles (late follicular phase), or withheld stimulation in culture
O
Outcome
Macrophage migration inhibitory factor (MIF) concentrations in serum, follicular fluid, and culture mediumsurrogate
HCG induces the elevation of serum and follicular fluid MIF concentrations, suggesting MIF is involved in the mechanism of ovulation.
Cite This Study
Wada et al. (1999) conducted an observational in In-vitro fertilization (IVF). Human chorionic gonadotrophin (HCG) stimulation vs. Baseline or withheld stimulation was evaluated on Macrophage migration inhibitory factor (MIF) concentrations. Human chorionic gonadotrophin (HCG) stimulation increased serum macrophage migration inhibitory factor (MIF) to a median of 92.6 ng/ml at 35 hours post-administration, compared to 12.1 ng/ml at baseline.