What question did this study set out to answer?

To summarize recent developments in asymmetric dearomatization of phenols and evaluate their role in constructing complex natural product targets.

December 24, 2015Organic & Biomolecular Chemistry

Asymmetric dearomatization of phenols

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Authors

WSWangsheng SunAcademy of Medical Sciences GLGuofeng LiShenzhen University LHLiang HongSun Yat-sen University

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Implication

Review demonstrates advances in phenol asymmetric dearomatization across catalytic systems, highlighting new synthetic routes toward complex natural products.

Key Points

To summarize recent developments in asymmetric dearomatization of phenols and evaluate their role in constructing complex natural product targets.
Reviewed literature on metal-catalyzed direct asymmetric dearomatization reactions.
Surveyed enantioselective transformations employing organocatalytic systems and hypervalent iodine reagents.
Transition metal catalysis, organocatalysis, and hypervalent iodine reagents provide diverse stereoselective pathways to convert planar phenols into dense, three-dimensional frameworks.
Asymmetric dearomatization strategies enable efficient, multi-step total synthesis of complex, biologically relevant natural products.

Cite This Study

Sun et al. (2015) studied this question.

synapsesocial.com/papers/6a9b135161e08bec6550b16f https://doi.org/10.1039/c5ob02526e

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Implication

Review demonstrates advances in phenol asymmetric dearomatization across catalytic systems, highlighting new synthetic routes toward complex natural products.

Asymmetric dearomatization of phenols

Discussion

Member takes

Implication

Key Points

Cite This Study

Asymmetric dearomatization of phenols

Discussion

Member takes

Implication

Key Points

Cite This Study

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