What question did this study set out to answer?

To summarize recent developments in catalytic asymmetric dearomatization reactions that convert simple phenol and aniline derivatives into complex chiral structures.

January 1, 2016Chemical Society ReviewsOpen Access

Catalytic asymmetric dearomatization (CADA) reactions of phenol and aniline derivatives

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Authors

WWWenting WuJiangxi University of Traditional Chinese Medicine LZLiming ZhangUniversity of California System SYShu‐Li YouUniversity College Dublin

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Implication

Review reveals advances in catalytic asymmetric dearomatization of phenol and aniline derivatives, highlighting synthetic routes to functionalized chiral molecules.

Key Points

To summarize recent developments in catalytic asymmetric dearomatization reactions that convert simple phenol and aniline derivatives into complex chiral structures.
Reviewed synthetic literature on catalytic asymmetric dearomatization (CADA) targeting phenol- and aniline-based chemical scaffolds.
Analyzed mechanistic approaches developed to overcome the thermodynamic barrier of aromaticity loss while controlling reaction selectivity.
Cataloged catalytic methodologies that reliably convert planar phenols into highly functionalized, optically active cyclohexadienones.
Identified versatile catalytic systems capable of steering stereochemical selectivity during the disruption of aromatic systems in phenol and aniline derivatives.

Cite This Study

Wu et al. (2016) studied this question.

synapsesocial.com/papers/69da11ec00ab073a27837a61 https://doi.org/10.1039/c5cs00356c

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Implication

Review reveals advances in catalytic asymmetric dearomatization of phenol and aniline derivatives, highlighting synthetic routes to functionalized chiral molecules.

Catalytic asymmetric dearomatization (CADA) reactions of phenol and aniline derivatives

Discussion

Member takes

Implication

Key Points

Cite This Study

Catalytic asymmetric dearomatization (CADA) reactions of phenol and aniline derivatives

Discussion

Member takes

Implication

Key Points

Cite This Study

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