Key result
Pretreatment with oxodipine significantly reduced the size of isoproterenol-induced myocardial infarcts in the apical and basal myocardium of rats (P < 0.05), whereas nitrendipine lacked effect.
Why the study?
Does oxodipine or nitrendipine reduce the size of experimental myocardial infarct in rats?
Does oxodipine or nitrendipine reduce the size of experimental myocardial infarct in rats?
Oxodipine, but not nitrendipine, significantly reduces the size of isoproterenol-induced myocardial infarcts in a rat model.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for differential dihydropyridine effects in experimental MI; does not support clinical translation.
The protective effect of either oxodipine or nitrendipine (4 mg/kg/twice daily, orally), two dihydropyridines exhibiting calcium channel-blocking properties, against induced infarct-like lesions was examined. Experimental myocardial infarct-like lesions were induced in rats by subcutaneous injection of isoproterenol (0.5 mg/kg). The lesions were mainly located in subendocardial areas of the free wall of the left ventricle, and were intramural at the apex and ventricular septum. Pretreatment with oxodipine significantly reduced the infarct size in the apical and basal myocardium (P < 0.05). Possible explanations for the lack of effect of nitrendipine pretreatment are discussed.
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Perez-Cao et al. (1994) studied Experimental myocardial infarct-like lesions. Oxodipine or nitrendipine was evaluated on Infarct size in the apical and basal myocardium (p=<0.05). Pretreatment with oxodipine significantly reduced the size of isoproterenol-induced myocardial infarcts in the apical and basal myocardium of rats (P < 0.05), whereas nitrendipine lacked effect.
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