Key result
Prophylactic dipyridamole reduces myocardial necrosis and preserves viable tissue after coronary occlusion in rats.
Why the study?
Does prophylactic dipyridamole reduce the size of myocardial infarction following coronary artery occlusion in a rat model?
Does prophylactic dipyridamole reduce the size of myocardial infarction following coronary artery occlusion in a rat model?
Prophylactic administration of dipyridamole reduces the size of myocardial infarction following coronary artery occlusion in a rat model.
Experimental myocardial infarction was induced in adult female Sprague-Dawley rats by ligation of the left coronary artery. During four weeks preceding the operation the animals were given dipyridamole (3 mg/kg initial body weight) i.p. twice a day 5 days per week. Control animals were given saline. Ten days after the operation the rats were killed and the hearts serially sectioned and stained. The volumes of necrotic and non-necrotic myocardial tissue were determined by morphometry on the histological sections. In the dipyridamole-treated animals the volume of non-necrotic myocardium was larger and the necrotic tissue volume smaller than in the control animals.
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Adolfsson et al. (1982) studied Experimental myocardial infarction. Dipyridamole vs. Saline was evaluated on Volumes of necrotic and non-necrotic myocardial tissue. Prophylactic dipyridamole treatment in rats resulted in a larger volume of non-necrotic myocardium and a smaller necrotic tissue volume following coronary artery occlusion compared to saline.
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