Why the study?
Does dipyridamole reduce infarct size in dogs with experimental myocardial infarction?
Population
12 dogs with experimental myocardial infarction induced by ligation of the left anterior descending coronary…
Comparison
Dipyridamole (3 mg/kg) vs Control group
Design
Preclinical
Follow-up
8 or 24 hours
Authors
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Reduces myocardial O2 demand determinants in canine experimental MI; leaves open translation to infarct size or clinical use.
Does dipyridamole reduce infarct size in dogs with experimental myocardial infarction?
In an experimental dog model of myocardial infarction, dipyridamole significantly reduced blood pressure, heart rate, and tension-time index.
Roberts et al. (1980) studied this question.
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