Key result
A comparative sequence analysis of 10 formins in Dictyostelium discoideum revealed that most share a common GBD/FH3-FH1-FH2-DAD architecture with fungal and metazoan formins.
Population
10 formin genes identified in the genome of the social amoeba Dictyostelium discoideum, compared with 62…
Comparison
Sequence analysis, phylogenetic tree… vs Formins from fungi, plants, invertebrates, and…
Design
Preclinical
Authors
Loading...
Does not alter clinical practice; extends evolutionary conservation data but leaves open functional relevance in human cardiovascular cells.
The study reveals a conserved GBD/FH3-FH1-FH2-DAD domain architecture in formins across Dictyostelium, fungi, and metazoa, implying a common regulatory mechanism for actin nucleation.
Muramoto et al. (2005) studied this question. Comparative sequence analysis was evaluated. A comparative sequence analysis of 10 formins in Dictyostelium discoideum revealed that most share a common GBD/FH3-FH1-FH2-DAD architecture with fungal and metazoan formins.