Key result
Fetal cardiac intervention shows promise for alleviating right ventricular dysfunction in congenital heart disease, potentially improving postnatal adaptation and long-term function.
Why the study?
While fetal cardiac intervention has successfully alleviated left ventricular dysfunction, whether it can also alleviate right ventricular dysfunction is being explored to expand its use and improve outcomes.
Does fetal cardiac intervention improve postnatal adaptation and long-term function in fetuses with right-sided heart disease such as pulmonary atresia with intact ventricular septum?
Does fetal cardiac intervention improve postnatal adaptation and long-term function in fetuses with right-sided heart disease such as pulmonary atresia with intact ventricular septum?
Fetal cardiac intervention may be a promising approach to alleviate right ventricular dysfunction in congenital heart disease, potentially improving postnatal outcomes.
Fetal intervention remains investigational; leaves open its role in right ventricular outflow obstruction pending prospective trials.
Congenital heart disease (CHD), the most common of birth defects, can be serious enough to require a lifetime of medical care including multiple surgeries or other interventions. Advances in ultrasound technology and a better understanding of the progression of CHDs have made it possible to intervene in utero. This early stage intervention allows the still plastic cardiovascular system to return to a more normal trajectory thus sparing the newborn from negative consequences to morbidity and mortality. Fetal cardiac intervention (FCI) has been successful for the alleviation of left ventricular dysfunction resulting in remarkably positive outcomes for many families. Promising results support that FCI may also be useful in alleviating right ventricular dysfunction. This bodes well for expanding the use of FCI to lead to better postnatal adaptation and improved long-term function for more children with CHD.
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James Strainic (2019) conducted a review in Congenital heart disease (pulmonary atresia with intact ventricular septum). Fetal cardiac intervention was evaluated. Fetal cardiac intervention shows promise for alleviating right ventricular dysfunction in congenital heart disease, potentially improving postnatal adaptation and long-term function.
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