Key result
Fetal cardiac intervention is proposed to halt disease progression and improve postnatal outcomes for fetuses with critical semilunar valve stenosis or atresia.
Why the study?
Does fetal cardiac intervention improve postnatal outcomes and prevent intrauterine death in fetuses with critical congenital heart disease?
Does fetal cardiac intervention improve postnatal outcomes and prevent intrauterine death in fetuses with critical congenital heart disease?
Fetal cardiac intervention offers a potential strategy to halt disease progression and improve postnatal outcomes in fetuses with critical congenital heart disease.
Hypothesis-generating for fetal intervention in critical semilunar valve disease; leaves open prospective trials on postnatal outcomes.
Surgery for congenital heart disease is now often performed in the first months of life because mortality is higher and myocardial damage more serious in unoperated children or those undergoing delayed surgery. Fetal cardiac intervention may prove a logical extension and has been proposed for fetuses with critical semilunar valve stenosis or atresia. Early ventricular decompression may halt disease progression, alter the natural history and improve postnatal outcomes either by preserving a two-ventricle circulation or by improving the outlook for single-ventricle candidates because of a healthier myocardium and pulmonary bed. Without intervention, fetuses with a closed interatrial septum may develop circulatory failure resulting in hydrops and intrauterine death, whereas in utero balloon atrial septostomy may stabilise the situation and increase duration of pregnancy.
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Helena M. Gardiner (2009) conducted a review in Congenital heart disease (critical semilunar valve stenosis or atresia). Fetal cardiac intervention was evaluated. Fetal cardiac intervention is proposed to halt disease progression and improve postnatal outcomes for fetuses with critical semilunar valve stenosis or atresia.
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