Key result
Deep sequencing of FMDV from 6 infected cattle identified 5 consensus level variants and 104 sub-consensus variants, revealing distinct viral populations evolving independently at different lesion sites.
Observational (n=6)
No
Deep sequencing of foot-and-mouth disease virus in infected cattle reveals complex intra-host viral swarm structures evolving independently at different lesion sites.
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Compartmentalized FMDV evolution at lesions in cattle; leaves open effects on transmission or vaccine response.
King et al. (2016) conducted an observational in Foot-and-mouth disease (FMD) virus infection (n=6). Deep sequencing of FMDV populations was evaluated on Viral sequence diversity (consensus and sub-consensus variants). Deep sequencing of FMDV from 6 infected cattle identified 5 consensus level variants and 104 sub-consensus variants, revealing distinct viral populations evolving independently at different lesion sites.
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