Key result
In pregnant women with organic heart disease, cyanotic lesions and poor cardiac status control were associated with significantly higher maternal mortality, morbidity, and intrauterine growth restriction.
Observational (n=101)
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Pregnant women with organic heart disease, particularly those with uncorrected cyanotic congenital heart disease or poor pre-pregnancy functional class, are at high risk for maternal and fetal complications.
A total of 122 pregnancies in 101 women with organic heart disease were reviewed. The incidence of organic heart disease in pregnant women was 0.25%. The ratio of rheumatic to congenital heart disease was 1.0 to 1.5. In the congenital heart disease group, IUGR was more frequent in the cyanotic group as were preterm births. Patients with cyanotic lesions had a significantly higher maternal mortality rate than those with acyanotic lesions. The cyanotic group without surgical correction had a significantly higher maternal mortality rate and more IUGR than those with correction. Congestive heart failure was the most common maternal complication, with a rate of 38.1%. The patients with good cardiac status control during pregnancy developed less IUGR, had fewer preterm births, less maternal morbidity and less maternal mortality than those in poor condition. Patients in functional classes I and II before pregnancy carried less risk of maternal morbidity than those in classes III and IV.
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Hsieh et al. (1993) conducted an observational in Organic heart disease in pregnancy (n=101). Cyanotic lesions and poor cardiac status vs. Acyanotic lesions and good cardiac status was evaluated on Maternal mortality, morbidity, intrauterine growth restriction (IUGR), and preterm births. In pregnant women with organic heart disease, cyanotic lesions and poor cardiac status control were associated with significantly higher maternal mortality, morbidity, and intrauterine growth restriction.
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