Key result
cAMP-PDE inhibitors produced complete relaxation of U46619-induced contractions in human internal mammary artery rings, and amrinone attenuated norepinephrine-induced constriction to 38% (P<0.001).
Why the study?
Do phosphodiesterase inhibitors reverse constriction in human internal mammary artery rings in vitro?
Population
Human internal mammary artery (IMA) rings in vitro
Comparison
Papaverine and cyclic adenosine monophosphate… vs Control rings (for pretreatment experiment)
Design
Preclinical
Authors
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Should not yet change perioperative IMA management; leaves open need for in vivo human trials.
Do phosphodiesterase inhibitors reverse constriction in human internal mammary artery rings in vitro?
p-value: p=<0.001
cAMP-PDE inhibitors can reverse internal mammary artery spasm in vitro, suggesting potential therapeutic utility after myocardial revascularization.
Salmenperä et al. (1996) studied Internal mammary artery spasm (in vitro model). cAMP-PDE inhibitors (amrinone, enoximone, milrinone) vs. Control rings was evaluated on Reversal of constriction of human IMA rings induced by U46619 or norepinephrine (p=<0.001). cAMP-PDE inhibitors produced complete relaxation of U46619-induced contractions in human internal mammary artery rings, and amrinone attenuated norepinephrine-induced constriction to 38% (P<0.001).
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