Key result
Reactive oxygen species generated sequentially by NOX4, NOX2, and mitochondria drive the onset and progression of adipocyte insulin resistance and adipose tissue inflammation across stages of obesity.
Design
Review
Authors
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Potential stage-specific ROS targets in obesity merit exploration; leaves open whether NOX or mitochondrial modulation alters clinical outcomes.
This review highlights the stage-dependent sources of reactive oxygen species (NOX4, NOX2, and mitochondria) in the progression of obesity-induced adipose tissue inflammation and insulin resistance, suggesting potential stage-specific therapeutic targets.
Chang Yeop Han (2016) conducted a review in Obesity and Insulin Resistance. Reactive Oxygen Species was evaluated. Reactive oxygen species generated sequentially by NOX4, NOX2, and mitochondria drive the onset and progression of adipocyte insulin resistance and adipose tissue inflammation across stages of obesity.
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