Key result
Laser-nephelometry demonstrated a very good correlation with electroimmunoassay for the rapid and reliable determination of proteins in serum and cerebrospinal fluid.
Why the study?
Does Laser-nephelometry accurately determine proteins in serum and CSF compared to electroimmunoassay?
Does Laser-nephelometry accurately determine proteins in serum and CSF compared to electroimmunoassay?
Laser-nephelometry is a rapid and reliable technique for determining proteins like alpha2-macroglobulin in serum and CSF, which is useful for assessing the blood-CSF barrier.
May enable faster protein assays in serum and CSF; leaves open prospective validation for blood-CSF barrier assessment.
The Laser-nephelometric technique is characterized by its easy handling, accuracy, good reproducibility and especially by the short time in which reliable results are available. A very good correlation was found between the results obtained by the electroimmunoassay and those obtained by Laser-nephelometry. In both techniques alpha2-macroglobulin is the largest serum protein that can be determined in normal unconcentrated cerebrospinal fluid (CSF). This is of diagnostic significance, since the serum/CSF ratios of both albumin and alpha2-macroglobulin are used as a parameter for the blood-CSF barrier condition.
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Schliep et al. (1978) studied Protein determination in serum and cerebrospinal fluid. Laser-nephelometry vs. Electroimmunoassay was evaluated on Correlation between Laser-nephelometry and electroimmunoassay. Laser-nephelometry demonstrated a very good correlation with electroimmunoassay for the rapid and reliable determination of proteins in serum and cerebrospinal fluid.
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